2/20/2023 0 Comments Affinity definitionBy agreed-upon convention of pharmacology, lower case "k" is used to denote rate constants such as k on and k off, whereas uppercase K is used for equilibrium constants (such as K d). The exact origins of "k" are lost in antiquity, and one can only assume that "k" stands for konstant, from German. Who decided we were going to call things k something, and why? Well. At this point, the relationship between k on and k off will stabilise.Ī moment of silence for nomenclature. When the system is allowed to rest for an infinitely long time these reactions will run to an equilibrium, where there will be some constant concentration of free drug, unbound receptor and drug/receptor complexes. In human language, the population of drug molecules and receptor molecules combine at a certain rate k on, and then separate again at another (possibly different) rate k off. The relationship of drugs combining with their receptors can be described as this: The major factors which affect affinity and dissociation constant in clinical pharmacology are temperature and the presence of a catalyst.Affinity in chemistry is the tendency of dissimilar chemical species to form chemical compounds.When K a is high, K d is low, and the drug has a high affinity for the receptor (fewer molecules are required to bind 50% of the receptors).Association constant (k a or K a ) is the opposite of K d.Dissociation constant (K d ) is the rate constant of dissociation at equilibrium, defined as the ratio k off / k on.k onis the rate constant of association of the drug to the receptor.k off is the rate constant of dissociation of the drug from the receptor.
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